Is prenatal diet associated with the composition of the vaginal microbiome?

摘要: Background The vaginal microbiome has been associated with adverse pregnancy outcomes, but information on the impact of diet on microbiome composition is largely unexamined. Objective To estimate the association between prenatal diet and vaginal microbiota composition overall and by race. Methods We leveraged a racially diverse prenatal cohort of North Carolina women enrolled between 1995 and 2001 to conduct this analysis using cross‐sectional data. Women completed food frequency questionnaires about diet in the previous 3 months and foods were categorised into subgroups: fruits, vegetables, nuts/seeds, whole grains, low‐fat dairy, sweetened beverages and red meat. We additionally assessed dietary vitamin D, fibre and yogurt consumption. Stored vaginal swabs collected in mid‐pregnancy were sequenced using 16S taxonomic profiling. Women were categorised into three groups based …