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摘要: We agree with Cereda et al. that obesity and central obesity confers with it a state of inflammation and this may also contribute to cognitive impairment and dementia risk. Unfortunately measures of physical activity were not available so it is unknown what effect this would have on the association between midlife central obesity status and dementia risk.We also concur that visceral adipose tissue itself is the likely culprit in the association between central obesity and increased dementia risk. Hopefully, future studies will investigate possible actions of visceral adipocytes on the brain and effects of an altered adipokine milieu on cognitive status.[12]