Should Liver Metastasis of Pancreatic Ductal Adenocarcinoma Be Resected?

摘要: Purpose: Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancer with a 5-year overall survival not exceeding 10%. At time of diagnostic 50% of PDAC are metastatic. Following current guidelines, metastatic PDAC should be exclusively treated by chemotherapy. However, with development of (combined-) chemotherapy and ablations techniques, some authors have reported their results of metastasis resection of PDAC. The liver being the most represented organ for PDAC dissemination, the aim of this study was to review the published cohorts of patients with PDAC undergoing resection or ablation of liver metastasis (LM) and to assess the criteria used for selection of patients.Method: We used the PRISMA method for the screening and selection of articles in the Pubmed database.Results: 21 articles were included in this review with a total of 912 patients with exclusive LM of PDAC. 814 (89 …