Effectiveness of Treatments Against Helicobacter Pylori According to Resistance to Clarithromycin: Data from the European Registry on Helicobacter Pylori Management (HP-EuReg)

摘要: Introduction Antibiotic resistance is the main factor influencing the efficacy of treatments to eradicate the infection by Helicobacter pylori (H. pylori). The treatments including clarithromycin are the most frequently used in first-line; however, the bacterial resistance to clarithromycin in treatment-naīve patients in Europe is, overall, >20%. Aims & Methods To assess the effectiveness of first-line H. pylori treatments in Europe according to the resistance to clarithromycin. Non-interventional, prospective, multicenter, international European registry on the management of H. pylori (Hp-uReg). All culture-diagnosed infected adult patients were registered at AEG-REDCap e-CRF from 2013 to 2021. Per-protocol (PP) analysis was performed based on the presence or absence of bacterial resistance to clarithromycin in treatment-naīve patients. The data was subject to quality control. Results In total, 2,479 culture-naīve patients …