707: MULTIPLE INJECTIONS OF ENTERIC NEURAL STEM CELLS RESTORES COLONIC FUNCTION IN NOS-NULL MICE

摘要: AGAA b st ra ct s mice, and since DEX decreased gut BDNF levels, we infer that stress-induced increase in glucocorticoid signaling delayed gut transit by suppressing enteric BDNF levels. Increased susceptibility of T1 KO mice to SID highlights the important role of the truncated TrkB. T1 receptor in maintenance of normal gut motility during acute and moderate stress. Thus, our data implicates altered BDNF-TrkB. T1 signaling in the etiology of SID. Figure 1 705 INTRACELLULAR STORES IN ENTEROENDOCRINE MECHANO-TRANSDUCTION Kaitlyn R. Knutson, Sara Whiteman, Constanza Alcaino, Isabelle W. Finholm, David R. Linden, Gianrico Farrugia, Arthur Beyder BACKGROUND: Enteroendocrine cells (EECs) are specialized sensors of luminal forces and chemicals in the gastrointestinal (GI) epithelium that respond to stimulation with a release of signaling molecules, such as serotonin (5-HT). For mechano …