Intermediate Malignant and Malignant Tumors of Soft Tissue Featuring a Spindle Cell Morphology

摘要: Spindle cells are generally (and sometimes erroneously) regarded as the archetype of mesenchymal neoplasia. Not surprisingly, soft tissue sarcomas with spindle cell morphology most likely represent the largest group (approximately onethird) of all mesenchymal malignancies, and include lesions such as leiomyosarcoma or synovial sarcoma that rank among the most common sarcoma histotypes. The morphologic approach to spindle cell sarcomas follows the same rules outlined in Chapter 1. The key to proper recognition is the variable combination of cell shape, pattern of growth, background, and type of vascularization. As an example, a superficial cellular spindle cell neoplasm organized in a herringbone pattern of growth most likely represents a fibrosarcomatous dermatofibrosarcoma protuberans, whereas a patternless spindle cell proliferation featuring cellular variation and a hemangiopericytoma-like …