B. infantis EVC001 Colonization in Breastfed Infants Modulates Cytokine Profile Linked to Autoimmune and Allergic Diseases

摘要: The intestinal microbiome plays a critical role in the development of the immune system, including the development of specific CD4+ T cell subtypes, T helper (Th) 1, Th2, Th17 and T regulatory (Treg) cells (each with a characteristic cytokine profile), which can have numerous long-term health consequences. Certain cytokines, including IL-4, IL-13, and IL-17A, are linked to the development of allergic and autoimmune diseases, whereas IFN-β has been shown to reduce the induction of Th1 and Th17 cells while increasing IL-10-producing Treg cells. Given the pleiotropic activities of these cytokines, including the coordination of tissue inflammation, infiltration, and destruction, we evaluated fecal cytokines from breastfed infants fed B. infantis EVC001 (EVC001) during the first 60 days of life. Stool samples were collected at Day 6 (baseline) and day 60 of life from exclusively breastfed infants (n= 40) randomly selected …