Anti‐Tumor Effect of Embryonic Stem Cell Derived Exosomes in Triple Negative Breast Cancer: Potential Role of TCF7‐E‐Cadherin and VEGF

摘要: Background Triple Negative Breast Cancer (TNBC) is an aggressive form of cancer and accounts for 10‐20 % of all breast cancer types. TNBC patients are widely treated with chemotherapeutic drugs such as doxorubicin (Dox), which is a primary standard of care. Dox treatment results in unwanted side effects including cardiac dysfunction and skeletal muscle weakness. We previously demonstrated the anti‐tumor effects and cardioprotective effects of embryonic stem cell derived exosomes (Es‐Exos) in the xenograft model of TNBC. The purpose of this study was to identify the biomolecules present in Es‐Exos, which may be linked to the anti‐tumor effects in the xenograft model. Methods and Results Orthotopic xenograft model of TNBC was generated by injecting human MDA‐MB‐231‐Tom‐Luc cell line in mammary intraductal T4 region of nude mice. Non‐tumor bearing female mice were used as control (NT …