Breaking Advances

摘要: Afshar-Serle and colleagues demonstrate that T cells can block lymphoma. Whereas loss of the tumor suppressor BLIMP1 (PRDM1) or deregulated expression of the oncogene BCL6 are common in diffuse large B-cell lymphomas (DLBCL), targeted mutations of either gene in mice rarely causes lymphoma. In mice with Blimp1 deficiency or Bcl6 overexpression in the B lineage, impairment of T-cell control resulted in DLBCL-like disease, which could be eradicated by polyclonal CD8 T cells in a T-cell receptor, CD28, and Fas ligand–dependent manner. Thus, transformation of mature B cells requires mutations that impair intrinsic differentiation processes and also permit escape from T cell–mediated tumor surveillance.(Image courtesy of Wikimedia Commons.)