Impact of WHO 2016 update and molecular markers in pleomorphic xanthoastrocytoma

摘要: Background: There is a relative paucity of data regarding outcomes of pleomorphic xanthoastrocytomas (PXA) particularly with respect to the impact of emerging molecular markers. We present our institutional experience of PXA and correlate their outcomes with various clinical and pathological factors.Methods: Between 2006 to 2016, 37 patients with histologically verified PXA form the study cohort. All patients underwent maximal safe resection; those who had good resection, low MIB-1 index and young age were observed. Adjuvant radiotherapy was given in patients with atypical features on histology, high MIB-1 index and recurrence after first surgery or with significant residual disease. Patients diagnosed with anaplastic PXA were managed by multi-modality approach comprising maximal safe resection, radiotherapy and systemic therapy. BRAFV600E mutation testing was attempted in all 37 paraffin embedded …