Associations with youth psychotic-like experiences over time: Evidence for trans-symptom and specific cognitive and neural risk factors.

摘要: The current study examined whether impairments in cognitive and neural factors at baseline (ages 9–10) predict initial levels or changes in psychotic-like experiences (PLEs) and whether such impairments generalize to other psychopathology symptoms (ie, internalizing and externalizing symptoms). Using unique longitudinal Adolescent Brain Cognitive Development Study data, the study examined three time points from ages 9 to 13. Univariate latent growth models examined associations between baseline cognitive and neural metrics with symptom measures using discovery (n= 5,926) and replication (n= 5,952) data sets. For symptom measures (ie, PLEs, internalizing, externalizing), we examined mean initial levels (ie, intercepts) and changes over time (ie, slopes). Predictors included neuropsychological test performance, global structural MRI, and several a priori within-network resting-state functional …