Morphological and Ultrastructural Analysis of the Adrenal Gland in Hypertensive Mice

摘要: Renovascular hypertension is consequence of pathologic activation of the renin-angiotensinaldosterone system induced by renal artery stenosis. Aldosterone is a mineralocorticoid hormone synthesized by the adrenal glands that has several regulatory functions to help the body maintain normal volume status and electrolyte balance. Aldosterone secretion is controlled in part by angiotensin II and potassium levels [1, 2]. However, the literature is controversial about structural changes of the adrenal gland in hypertensive conditions [3]. Thus, the aim of this study was to evaluate the morphological effects of agiotensin II-dependent renovascular hypertension in adrenal gland. Male C57BL/6 mice (n= 20), averaging 23 g, were subjected to two-kidney, one-clip (2K1C) renovascular hypertension using stainless steel clips (0.12 mm opening width, Exidel SA, Switzerland) or sham operation. Animals were euthanized in a …