Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic.

摘要: Methods: In 450 participants with obesity, body composition, resting energy expenditure, satiety, satiation, eating behavior, affect, and physical activity were measured by validated methods and questionnaires. These variables were used to classify obesity phenotypes. Subsequently, in a 12‐month real‐world observational follow‐up performed in a weight management center, 312 patients who requested weight management treatment were given appointments to receive standard medical weight management (n= 228) or phenotyping and phenotype‐guided weight management (n= 84) with antiobesity medications: phentermine, phentermine/topiramate, bupropion/naltrexone, lorcaserin, and liraglutide. The primary outcome was weight loss at 12 months.Results: Four phenotypes of obesity were identified in 382 of 450 participants (85%): hungry brain (abnormal satiation), emotional hunger (hedonic eating), hungry …