β-catenin Antisense Oligonucleotides Protect Mice Against Diet-Induced Insulin Resistance and Regulate Liver Lipid Metabolism: 674

摘要: Background: Macrophage activation plays a crucial role in the development of metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is known as a phenotype of metabolic syndrome in the liver. Macrophage migration inhibitory factor (MIF) is involved in both innate and adaptive inflammatory response and regulates macrophage accumulation/activation. We have previously reported MIF-knockout mice (MIF-KO) is resistant against T-cell mediated (concanavalin A-induced) hepatitis. Recently, anti-fibrogenic effects of MIF has been reprted in chronic CCL4 and TAA-induced liver injury. However, the precise role of MIF in NAFLD is not clear. Methods: MIF-KO and wild-type (WT) were fed either a control or a high-fat diet for 24-weeks and 72-weeks. Hepatic inflammation, steatosis, fibrosis, and liver tumor development were examined. Results: MIFKO showed more incresed body weight, liver/bodyweight ratio …