作者: A Dey , R Parr , N Aras , A Balogh , J Bostock
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摘要: We examined differences in bone mineral density of young adults (15-50 years) across a range of races and countries. An age-stratified total of 3752 subjects were recruited at 11 centres in 9 countries. Femoral neck BMD was measured and standardised (sBMD, g/cm2) using the European Spine Phantom. There were highly significant differences in mean weight, height, and sBMD between countries (p< 0.001). Moscow had the highest mean sBMD and was used as the reference population in linear regression models. Following adjustment for age, weight and height, differences in sBMD persisted between centres for both men and women. Centre sBMD difference Significance Santiago-0.001 ą0. 013 0.930 Ankara-0.012 ą0. 012 0.318 Obninsk-0.025 ą0. 017 0.131 Beijing-0.025 ą0. 011 0.026 Toronto-0.029 ą0. 014 0.035 Singapore-0.047 ą0. 012< 0.001 Sau Paulo-0.058 ą0. 014< 0.001 Manila-0.062 ą0. 014< 0.001 Debrecan-0.071 ą0. 012< 0.001 Shanghai-0.088 ą0. 013< 0.001 Table. Differences in female sBMD (meanąSEM) compared to Moscow. Approximately 20-30% of the global variation in sBMD is accounted for by country of origin and anthropomorphic differences. Significant differences exist in young adult bone mass which, if persisting into old age, may contribute to 2-3 fold difference in fracture risk.