Performance of ACC/AHA Cardiovascular Disease Risk Equations in Indigenous Australians With and Without Diabetes: The CRISP Study Collaboration

摘要: Introduction: Atherosclerotic cardiovascular disease (ASCVD) remains a major public health issue for many Indigenous populations, including Indigenous Australians because of earlier onset diabetes and longer duration of risk factor exposure at any given age. Using data from the Cardiovascular Risk in IndigenouS People (CRISP) study, we assessed the performance of the ACC/AHA ASCVD risk equations. Methods: We undertook an individual-participant meta-analysis on 2,066 Indigenous Australians (57% women) from five population-based cohorts aged 40-79 years without an ASCVD history. Baseline data were harmonised and 312 prospective ASCVD outcomes were collected using data-linkage to hospital databases and the National Death Index. Predicted 10-year ASCVD risks (95%CI) were determined using the ACC/AHA equations for non-Hispanic white and African American men and women. χ2 tests …