Process parameter optimization for reproducible fabrication of layer porosity quality of 3D-printed tissue scaffold

作者: Andrew Chung Chee Law , Rongxuan Wang , Jihoon Chung , Ezgi Kucukdeger , Yang Liu

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摘要: Bioprinting, or bio-additive manufacturing, is a critical emerging field for transforming tissue engineering regenerative medicine to produce biological constructs and scaffolds in a layerwise fashion. Geometric accuracy and spatial distribution of scaffold porosity are critical factors associated with the quality of bio-printed tissue scaffolds. Determining optimal process parameters for tissue scaffold microextrusion 3D printing by traditional trial-and-error approaches is costly, labor-intensive, and time-consuming. In addition, effective in-process sensing techniques are needed to observe internal multilayer scaffold structures, such as porosity. Therefore, an in-process sensing platform based on integrated light scanning and microscopy was proposed to acquire in-process layer information during the fabrication of polymeric and hydrogel scaffolds. This work implements a customized sensing platform consisting of a 3D …

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