Does an isolated choroid plexus cyst or cysts really indicate fetal karyotyping?

摘要: Fetal choroid plexus cysts (CPCs) are hypoechoic structures within the choroid plexus of the lateral brain ventricles. They are symmetrical in appearance, have sharply circumscribed margins and my be either unilateral or bilateral. On the follow-up examination they are rarely found after 24 weeks of pregnancy. In anatomical and structural terms, CPCs are of no serious significance for the pregnancy; however, they have been associated with trisomies (mostly 18 and less commonly 21) and other chromosomal abnormalities. Several authors have suggested further evaluation of pregnancy for an additional risk factor before undertaking further invasive diagnostic tests. Recent studies have suggested that isolated choroid plexus cysts are not an absolute indication for invasive prenatal diagnosis. A choroid plexus cyst associated with other ultrasonographic markers or with other risk factors such as advanced maternal age should be an idication for offering prenatal diagnosis.