Signal processing of sub-kHz FF-SS-OCT for optoretinography of the human retina

摘要: In this presentation we will evaluate the signal processing steps required to obtain stimulus-evoked nm-scale changes in the photoreceptor outer segment (OS) length using full field swept source optical coherence tomography (FF-SS-OCT). Evaluation of stimulus-evoked OS length changes is the basis of photoreceptor optoretinography (ORG), an emerging test of retinal function. To allow cellular resolution, an adaptive optics (AO) enhanced FF-SS-OCT system was constructed. This system allows up to kHz volume acquisition rates, which greatly reduce retinal motion artifacts. Specifically, the effects of wave number calibration, dispersion compensation, and application of short-time Fourier transform (STFT) on image quality metrics, SNR of individual OCT volumes, and extracted phase noise will be presented.