Prevalence of vitamin C deficiency in adult hospital patients in high-income countries: A scoping review

摘要: Methods: A systematic scoping review was conducted following the PRISMA-ScR framework. Six databases were searched. Eligibility included hospital inpatients in high-income countries and VCD prevalence using World Health Organisation reference standards (plasma/serum concentration< 11.4 μmol/L, whole blood< 17 μmol/L). Cumulative prevalence of VCD in pooled studies was calculated using REVMAN 5.4.Results: Twenty-two studies from 8 countries were included, representing 23 articles. Cumulative prevalence of VCD was 26.6%(95% CI: 20.7-32.5; n= 2494), prevalence was highest in patients with severe illness and poor nutrition status, and scurvy was present in 18-48%(n= 581) of VCD patients. VCD status did not resolve during admission unless therapeutically replaced. Being retired (p= 0.015), and taking excessive alcohol and tobacco (p= 0.0003) were independent risk factors for VCD (n= 184 …