Distinct effects of Anterior Cingulate, Orbitofrontal and Prelimbic cortex lesions on decision-making in a Rat Gambling Task

摘要: Complex decision-making is profoundly impaired in psychiatric and neurological disorders (attention-deficit/hyperactivity disorder, addictions or frontal cortex lesions), but also in some healthy individuals for whom immediate gratification prevails over long-term gain. These deficits can be revealed experimentally using the Iowa Gambling Task (IGT). In order to explore the neurobiological bases of decision-making, we designed a Rat Gambling Task (RGT) analogous to the IGT. This test provides rapid and specific measure of adapted and maladapted decision-making using healthy rats. Like in humans, good but also poor decision-makers (preferring immediate larger reward despite suffering large loses or without any preference) can be identified within a single session. The effects of Orbitofrontal (OF), Anterior Cingulate (AC) or Prelimbique (PL) cortex lesions were compared to sham lesions on proportions of good …