901P Relationship between p16 and tumor-infiltrating lymphocytes in Peruvian patients with head and neck cancer

摘要: BackgroundHuman papillomavirus-16 (HPV-16) infection in Head and Neck Squamous Cell Carcinoma (HNSCC) has a different prevalence through worldwide regions, it influences prognosis and treatment response and p16 staining is its surrogate biomarker. The density and composition of tumor-infiltrating lymphocytes (TIL) reflect biology and prognosis in different malignancies. We characterize TIL in Peruvian patients with HNSCC. We evaluate the influence of clinicopathological features including p16 & ki67 staining in tumor cells over TIL level.MethodsCD3, CD8, p16, and Ki67 immunohistochemistry were performed on tissue microarrays (TMA), density of CD3/CD8 positive cells were analyzed with Visiopharm Tissuealign Software, and p16 status and ki67 level were evaluated by a pathologist. TIL was evaluated following the International TIL working group. Statistical analysis was performed with SPSS …