Anticholinergic drug burden and neurocognitive performance in the study of latinos-investigation of neurocognitive aging

摘要: Background: Studies of cumulative anticholinergic drug burden on cognitive function and impairment are emerging, yet few for Hispanics/Latinos.Objective: To examine associations between anticholinergic use and neurocognitive performance outcomes among diverse Hispanics/Latinos.Methods: This prospective cohort study included diverse Hispanic/Latino participants, enrolled in the Study of Latinos-Investigation of Neurocognitive, from New York, Chicago, Miami, and San Diego (n= 6,249). Survey linear regression examined associations between anticholinergic use (measured during baseline [Visit 1] and average 7-year follow up [Visit 2]) with global cognition, episodic learning, memory, phonemic fluency, processing speed, executive functioning, and average 7-year change.Results: Anticholinergic use was associated with lower cognitive global cognition (ß=–0.21; 95% CI [–0.36;–0.05]), learning (ß=–0.27 …