Carriers of Risk Alleles in TCF7L2 Have Impaired Postprandial GIP Secretion and Reduced Insulin Secretion During Infusion of GLP-1.

摘要: Common polymorphisms of the transcription factor 7-like 2 gene (TCF7L2) have been associated vwith Type 2 diabetes (T2D), presumably through impaired insulin secretion. T2D is associated with defects in the secretion and action of Glucagon Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP). The TCF7L2 gene is a transcription factor of the proglucagon gene which encodes the insulinotropic GLP-1 in the intestine, why an effect on incretin secretion and action has been hypothesized. We aimed to assess the influence of TCFTL2 polymorphisms on incretin hormone secretion and action in young non-diabetic men (n= 34) aged 24 yrs. We genotyped the rs12255372, rs7903146 and rs10885406 polymorphisms of TCF7L2. The secretion of incretin hormones and insulin was studied during a standard meal test, whereas the action of incretin hormones was studied during 2 hours …