Risk of developing pancreatic cancer in patients with chronic pancreatitis

摘要: Materials and Methods: We performed retrospective analysis of a dataset of 581 patients with definite CP, diagnosed between 2003 and 2018. Aetiology of CP was determined according to the MANNHEIM classification.Results: There were 371 (63.9%) males and 210 (36.1%) females (median age 57 years). During 3423 person years of observation, six pancreatic cancers were diagnosed (0.2% year). The mean time between diagnosis of CP and the occurrence of PDAC was 5.0 years (range 2.7–8.6). Diabetes mellitus (DM) was present in five of six (83.3%) patients with PDAC: in three patients before and in two after CP diagnosis. Pancreatic exocrine insufficiency (PEI) was present in five of six (83.3%) patients with PDAC: in two at a CP diagnosis and in three after diagnosis. The mean survival time was 4 months after the PDAC diagnosis (range 0.5–13). PDAC occurred significantly more often (p< 0.001) in two …