Association of Angiotensin Converting Enzyme (ACE) Gene insertion/deletion (I/D) Polymorphism with Obesity and Obesity Related Phenotypes in Malay Subjects.

摘要: Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been identified as a potential candidate gene for obesity. The aim of this study was to identify the genotypic and allelic frequencies of ACE gene I/D polymorphism and its association with anthropometric parameters, lipid profiles and the susceptibility for obesity in Malay subjects. This cross-sectional, comparative study involved 219 subjects; 94 obese and 123 non-obese as controls. Anthropometric and lipid profiles were measured according to the standard method, alongside with genotyping analysis by polymerase chain reaction (PCR). Anthropometric and lipid profiles were compared between groups, and the association of this polymorphism with obesity was evaluated. Genotypic frequencies of II (47.9%), DD (42.7%) and DD genotypes (9.6%) in normal group were compared with genotypic frequencies of II (54.5%), DD (36.6%) and DD genotypes (8.9%) in obese group (P= 0.620). The D allele distribution was 31.0% in normal comparing with 27.0% in obese group (P= 0.410). Anthropometric parameters and lipid profiles did not differ significantly between the genotypes. However, D allele carriers exhibit consistently higher triglycerides, total cholesterol and LDL-cholesterol levels than the non-carriers without statistical significance. The ACE gene I/D polymorphism is not associated with obesity and obesity related phenotypes in Malay subjects; a weak interaction effect between the D allele with lipid profiles is seen.