Resistin levels in patients with obstructive sleep apnoea syndrome–the link to subclinical inflammation?

摘要: Background: The role of resistin, a “new” white adipose tissue hormone, still needs to be established. Its linkage to insulin sensitivity and body mass was controversial in previous studies.Material/Methods: Twenty obese patients (BMI: 32.1±6.9 kg/m2) with obstructive sleep apnoea syndrome (OSAS)(Apnoea-Hypopnoea Index: 48.6±19.1, underwent measurements of resistin, interleukin-6 (IL-6), intracellular adhesion molecule-1 (ICAM-1), CRP and the insulin sensitivity index (ISI) by hyperinsulinaemic euglycaemic clamp before, 2 days and 2 months after onset of CPAP treatment.Results: Resistin remained unchanged during CPAP-therapy and was negatively correlated to ISI (r=–0.359; p= 0.006), the latter was significantly improved by CPAP (p< 0.001). In a correlation matrix, IL-6 and ICAM-1 were significantly (p= 0.001) correlated to resistin (p= 0.614 and 0.427). Changes of inflammatory markers under CPAP treatment were related to AHI, as well as resistin changes.Conclusions: In agreement with previous investigations, we could only demonstrate a weak linkage between ISI and resistin. However, at least in obese patients with OSAS, there is a close relation to subclinical inflammation (IL-6) and endothelial activation (ICAM-1).