Mechanisms Mediating the Anti‐inflammatory Effects of Eicosapentaenoic Acid in the APPswePS1dE9 Alzheimer's Mouse Model

摘要: Background Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder characterized by amyloid‐beta (Aβ) plaques, which may be exacerbated by obesity. We previously reported anti‐obesity and anti‐inflammatory effects of eicosapentaenoic acid (EPA), in diet‐induced obese mice. Therefore, the objective of this research is to determine whether EPA also protects against AD‐associated Aβ deposition. Method Male and female AD mouse model APPswePS1E9 transgenic (TG) and non‐TG wild type littermates (WT) were fed with low fat (LF), high fat (HF), or HF supplemented with 36g/kg EPA (EPA) for 8 months. Mice were metabolically phenotyped during the intervention and blood and tissues were collected at the end of the study. Cortex RNA was isolated, and changes in genes related to AD, obesity, and inflammation were measured. Data were analyzed by 3‐way ANOVA using GraphPad Prism …