Protective effects of eicosapentaenoic acid on metabolic features and cognitive function in the APPswePS1dE9 Alzheimer’s mouse model

摘要: Background Alzheimer’s disease (AD) is characterized by amyloid‐beta (Aβ) plaque deposition and may be exacerbated by aging‐induced neuroinflammation and obesity. We hypothesized that compared to high fat (HF) diets, FO with anti‐inflammatory and anti‐obesity properties, would reduce metabolic and cognitive dysfunctions in an AD amyloidogenic mouse model of obesity. Method Two‐month‐old, both sexes, APPswePS1E9 transgenic (TG) and non‐TG littermates were randomly assigned and fed low fat (LF), HF, or HF supplemented with FO for eight months (n=8‐10/group). Body weight and food intake were recorded weekly, and body composition was measured bi‐monthly. Glucose Tolerance Test (GTT) and Morris water maze (MWM) were measures at 5‐ and 9‐ months, respectively. At termination, blood and tissues were collected. Serum Aβ‐40 levels were measured by immune‐multiplexing …