Protective Effects of Eicosapentaenoic Acid on Adiposity and Amyloidogenic Features in the APPswePS1dE9 Alzheimer’s Mouse Model

摘要: ObjectivesAlzheimer’s disease (AD) is a degenerative brain disease characterized by atypical development of amyloid-beta (Aβ) plaques. We previously showed that eicosapentaenoic acid (EPA), found in fish oil exerted anti-obesity and anti-inflammatory effects in diet-induced obese (DIO) mice. Here we hypothesize that EPA will reduce both adiposity and neuroinflammation in an amyloidogenic Alzheimer’s DIO mouse model.MethodsTwo-month-old male and female APPswePS1E9 transgenic (TG) and non-TG littermates were randomly assigned to low fat (LF; 10% kcal fat), high fat (HF; 45% kcal fat), or HF supplemented with EPA (36 g/kg EPA) diets for eight months. Body weights were recorded weekly, blood and tissues were harvested at termination. Serum amyloid Aβ-40 (AD marker), leptin, adiponectin, and resistin (adiposity markers) levels were quantified by Multiplex assays (n = 6–7/group). Outcomes …