Assessment of Early Treatment Response Using a Fast and Robust MRI Protocol in Genetically Engineered Mouse Lung Cancer Models

摘要: For the purposes of pathology characterization and evaluation of new cancer treatments, a simple, fast and robust imaging protocol with high throughput is essential. We demonstrated that the IntraGate technique used in this study is a fast and simple way to image mouse lungs without the complication of cardiac and respiratory gating. The MRI lung imaging protocol established here showed increased SNR efficacy. We used this protocol to monitor the progression of adenocarcinomas and for evaluating the efficacy of the irreversible EGFR/HER2 inhibiter BIBW2992. Objective response to treatment with BIBW2992 was apparent even after a single treatment dose.