Regional cerebral blood flow measurement in patients with sickle cell disease using pseudo continuous arterial spin labeling

摘要: Sickle Cell Disease (SCD) is a genetic anemia with a high vascular occlusion occurrence rate. Detecting regional cerebral blood flow (CBF) abnormalities plays an important role in identifying SCD patients at risk of developing silent infarcts. Regional and global CBF for 7 adolescent SCD were measured using pseudo-continuous arterial spin labeling MRI, compared with the ones in 7 controls. Average CBF values were higher in patients (p= 0.01) in all cerebral artery territories.