Thalamo-cortical networks in subtypes of migraine with aura patients

摘要: BackgroundWe searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and migraine with complex neurological auras (MA+), ie with the addition of at least one of sensory or language symptom.Methods3T MRI data were obtained from 20 patients with MA and 15 with MA+ and compared with those from 19 healthy controls (HCs). We collected resting state data among independent component networks. Diffusivity metrics of bilateral thalami were calculated and correlated with resting state ICs-Z-scores.ResultsAs compared to HCs, both patients with MA and MA+ disclosed disrupted FC between the default mode network (DMN) and the right dorsal attention system (DAS). The MA+ subgroup had lower microstructural metrics than both HCs and the MA subgroup, which …