Compartmental Exudative Dynamics in Neovascular AMD: Volumetric Outcomes and Impact of Volatility in a Phase III Clinical Trial

摘要: PurposeTo examine retinal feature dynamics in eyes with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (anti-VEGF) therapy and the relationship of these features with visual acuity.DesignPost hoc analysis of the phase 3, randomized, HAWK nAMD clinical trial.ParticipantsParticipants randomized to the brolucizumab 6 mg or aflibercept 2 mg arms of the trial.MethodsSpectral domain optical coherence tomography (OCT) scans collected at 4-week intervals were analyzed using an automated machine learning-enhanced segmentation and feature-extraction platform with manual verification. Quantitative volumetric measures of retinal and exudative features were exported at multiple timepoints over 48 weeks. Volatility of exudative features was calculated as the standard deviation of each feature value during the maintenance phase (week 12–48) of …