FLIP-3 Study

摘要: This is the first study to analyze fluid based prognostication in Type 3 MNV in isolation. It reveals that the presence of only IRF might be associated with good visual acuity in this subgroup of n-AMD. Results of this study need to be strengthened with a prospective long term study.AbstractPurpose: To analyze the effect of fluid on visual acuity in cases of Type 3 macular neovascularization (MNV).Methods: This multi-centric, retrospective cohort study included eyes with treatment-naïve Type 3 MNV. Analysis of fluid in different compartments was performed. Group A included eyes with isolated intraretinal fluid (IRF), while Group B included eyes with IRF in conjunction with sub retinal fluid (SRF) and/or sub retinal pigment epithelial fluid (Sub-RPEF).Results: Eyes in Group A (31, 55.3%) had better BCVA of 20/50 snellen equivalent (0.42±0.31 logMAR) at baseline and 20/50 snellen equivalent (0.40±0.28 logMAR) at complete resolution compared to Group B with visual acuity of 20/80 snellen equivalent (0.64±0.35 logMAR)(p= 0.0181) at baseline and 20/100 snellen equivalent (0.70±0.40 logMAR)(p= 0.0021) at complete resolution. Subfoveal atrophy was more in Group B (82.6% 19/23) at complete resolution in comparison to Group A ((16/31, 51.6%). Eyes in Group B needed more anti-VEGF injections (10.3±9.0) for complete resolution compared to Group A (5.7±4.8).Conclusion: IRF might be associated with good visual acuity in Type 3 MNV in contrast to other forms of n-AMD. Furthermore, IRF in isolation might need fewer injections and could probably be associated with less subfoveal atrophy.