Quality of Life, Psychological Distress, and Prognostic Awareness Among Caregivers of Chimeric Antigen Receptor T-Cell Therapy Recipients

摘要: BackgroundCaregivers of patients treated with chimeric antigen receptor-T (CAR-T) cell therapy play a critical role helping with the patient care. Nevertheless, their experience during this intense therapy remains largely unaddressed. Thus, we aimed to longitudinally describe quality of life (QoL) and psychological distress (anxiety, depression), as well as prognostic awareness among caregivers and explore its association with baseline distress.MethodsWe conducted a longitudinal study of caregivers of patients undergoing CAR-T therapy and examined QoL (CAReGiverOncology Quality Of Life questionnaire), and psychological distress (Hospital Anxiety and Depression Scale) prior to CAR-T (baseline) and at days 7, 30, 90 and 180 post-infusion. At baseline, caregivers also completed the Prognostic Awareness Impact Scale, which examines cognitive understanding of prognosis, emotional coping with prognosis …