Antimalarial Activity of the Alkaloid Nitidine, isolated from a Kenyan Herbal remedy

摘要: Bioassay guided fractionations of extracts of Toddalia asiatica, a plant used by Pokot tribe in Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for range of chloroquine-susceptible and resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine