A Systematic Review Of The Manangement Of Relapsed/Refractory Follicular Lymphoma

摘要: Refractory follicular lymphoma is an indolent malignancy of follicular center cells where a subgroup of disease presents with relapse and refractoriness to treatment or transformation  to  aggressive  diffuse  large B cell lymphoma. Improved knowledge of the disease biology is expected to provide means of identifying refractory disease at diagnosis and new approach to their treatment. This systematic review of emerging  treatment  modalities  was  done with a view to identifying appropriate treatment of refractory or relapsed follicular lymphoma in resource poor settings. A  systematic  search  of  the  database  of MEDLINE, COCHRANE and EMBASE was done using the following words:  relapse/refractory follicular lymphoma, follicular lymphoma clinical trials, follicular lymphoma treatment guideline. Randomized  controlled  phase  II/III  trials were selected for review. National Comprehensive Cancer Network and …