A theoretical model for myocardial blood flow

摘要: A dominant characteristic feature of the coronary circulation in the beating heart is the difference in phase between arterial inflow and venous outflow. A need therefore exists to study the system by making simultaneous arterial and venous pressure and flow measurements. mathematical model is helpful in providing insight into the mechanisms involved. While many models have been developed for this purpose, most have concentrated on specific aspects of the total problem, such as phasic inflow and the diastolic pressure-flow relationship (1, 2), while very few (3) have been put to the test of comparison with measured phasic inflow and outflow. Another feature of the cororary circulation is that there is strong evidence for diastolic-systolic interaction (4), eg microspheres injected into the beating heart show a different transmural ranking of flows compared to those injected during a single long diastole. The endo/epi transmural distribution of blood flow, together with backflow in different layers (5), is also an important consideration.