Novel manganese carbon quantum dots as a nano-probe: Facile synthesis, characterization and their application in naproxen delivery (Mn/CQD/SiO2@ naproxen)

摘要: This study for the first time pursues two crucial aims of using Naproxen as a non-steroidal anti-inflammatory drug in a better, non-invasive setting and introducing a simple and biocompatible nano-carrier (Mn/CQD/SiO2) which is a magneto carbon quantum dots modified with mesoporous silica probe which can be served as a drug delivery and tracer system. SiO2 modification was done by mesoporous silica which improves biocompatibility and provides low cytotoxicity. Naproxen was conjugated to the nano-probe to form Mn/CQD/SiO2@naproxen and biodistribution was investigated. Physicochemical characteristics of the Mn/CQD/SiO2@naproxen were investigated using FT-IR, SEM, TEM, UV–Vis and BET. Antiproliferation assay using MTT assay was performed on HEK-293 cells to determine the cytotoxity of Mn/CQD/SiO2@naproxen. Relaxivity of Mn/CQD/SiO2 was examined thereafter. To investigate the …