Enhancing clot busting medication in stroke with directed drug convection using magnetic nano-particles

摘要: 0005 According to a first aspect of the invention, there is provided a method of preparing Surface modified ion oxide nanocomposites comprising:0006 dissolving FeC1. 6H2O and FeC14H2O in heated water comprising a Suitable biocompatible polymer; 0007 adding ammonium hydroxide and mixing, thereby producing a mixture; 0008 cooling the mixture to about room temperature; and 0009 recovering surface modified iron oxide nanocom posites from the mixture. 0010. The suitable biocompatible polymer may be selected from the group consisting of polyethylene glycol (PEG), poly (ethyl methacrylate)(PEMA) and glutamic acid. 0011. The surface modified iron oxide nanocomposites may have a diameter of approximately 7-20 nanometers.(0012. The FeC1. 6HO and the FeC14H2O may be mixed at approximately a 2: 1 ratio.(0013 The water may be heated to about 80 C. in a further aspect of the invention, there …