Tissue harmonic versus contrast‐enhanced harmonic endoscopic ultrasonography for the diagnosis of pancreatic tumors: Prospective multicenter study

摘要: Objectives This prospective multicenter study aimed to assess and compare the accuracy of tissue harmonic endoscopic ultrasonography (TH‐EUS) and contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) for differentiating pancreatic carcinoma from other pancreatic tumors. Methods Consecutive patients with solid pancreatic tumors were prospectively enrolled between August 2013 and December 2014. To assess the accuracy of TH‐EUS and CH‐EUS, we compared four parameters of TH‐EUS (fuzzy edge, irregular periphery, hypoechogenicity, and heterogeneous internal echogenicity) and four parameters of CH‐EUS (hypoenhancement and heterogeneous enhancement in the early and late phases, respectively) to investigate which parameter of each method was most suitable to diagnose pancreatic carcinomas. Interobserver agreement and the diagnostic ability of pancreatic carcinoma …