Rapid Determination of 24 Synthetic and Natural Cannabinoids for LC–MS-MS Screening in Natural Products and Drug Inspection Applications

摘要: Marijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world. Synthetic cannabinoids have similar psychotropic effects to the natural ones and are rapidly being integrated by the illicit market. To deal with their expanding number and diversity, a targeted and untargeted liquid chromatography–tandem mass spectrometry (LC–MS-MS) screening method was developed, allowing for the simultaneous analysis of 24 synthetic and natural cannabinoids in 8 min for a wide variety of samples such as herbal smoking mixtures, incense sticks, serums, and cannabis plant material. The particular advantage of this LC–MS-MS method is that the full scan event in the MS acquisition provides accurate masses for all detected species and thus allows postanalysis identification of initially untargeted compounds.