EE377 The Clinical & Economic Burden of Treatment Resistant Depression in the GCC: The Kingdom of Saudi Arabia, Kuwait and the United Arab Emirates

摘要: ObjectivesTo evaluate the economic and clinical burden of treatment-resistant depression (TRD) across the countries under Gulf Cooperation Council-the Kingdom of Saudi Arabia (KSA), Kuwait, and the United Arab Emirates (UAE) from a payer’s perspective.MethodsA Microsoft Excel® based Markov model was developed to assess overall burden of TRD among adults with major depressive disorder (MDD). Assessments were based on the treatment pathway for TRD patients and their health-states in response to treatment. Data for the model adaptation were retrieved from literature and validated by country-specific key opinion leaders. The cycle-length and time-horizon used in the model were 4 weeks and 1-year, respectively. Key model inputs included MDD prevalence, number of patients who progressed to TRD and cost components which included both direct and indirect costs.ResultsAt the end of 1-year …