Abstract 2470 A copper-containing antibiotic produced by Pseudomonas

摘要: Pseudomonas species colonize and infect a broad range of eukaryotic hosts. Infection by these bacteria can significantly impact the diversity and composition of the microbiota of the hosts. Pseudomonas produce many natural products, including antibiotics, toxins, and signaling molecules. These molecules play essential roles in microbe-microbe and microbe-host interactions. This talk describes the identification, biosynthesis, and activity of an unusual copper-containing antibiotic, fluopsin C, produced by the opportunistic human pathogen Pseudomonas aeruginosa. The biosynthesis of fluopsin C requires five enzyme-catalyzed reactions, including a unique methine excision reaction. The biosynthetic gene cluster of fluopsin C is conserved in nearly 5,000 P. aeruginosa genomes and distributed in many other human pathogens and plant colonizers. Thus, fluopsin C likely plays a conserved physiological role in …