Fibrin/Thrombin patches and glues in a pre-clinical model of endoscopic skull base hemorrhage

摘要: Aim: To demonstrate efficacy, ease of application and safety of a fibrin/thrombin patch (TachoSil [Baxter]) and fibrin/thrombin glue (Evicel [Johnson & Johnson]) combined with oxidized cellulose (Surgicel snow [Johnson & Johnson]) in the acute management of major vessel hemorrhage in endoscopic skull base surgery using an endoscopic model of carotid artery bleeding in sheep, and compare these with muscle patch and anastoclip controls.Methods: Twelve merino sheep underwent neck dissection and application of an endoscopic trainer over the carotid artery. Standardized 4-mm linear incisions were made in the artery and the experimental patches used to control the hemorrhage with a 2 surgeon endoscopic technique. Hemodynamic changes, time to hemostasis and volume loss were measured. Animals were recovered for 3 months and underwent MRI angiography to determine incidence of …