BLACK RACE PREDICTS POOR COMPLIANCE BUT HIGHER PROSTATE CANCER RISK IN A MULTINATIONAL REPEAT BIOPSY COHORT: RESULTS FROM REDUCE: MP34-04

摘要: METHODS: Analysis of 7,415 men (2.4% black, 97.6% white) with complete data from REDUCE, a 4yr, multicenter, double-blind, placebo-controlled RCT testing dutasteride vs placebo on PC risk. Eligible men were 50-75 yrs old, had a single, negative, pre-study biopsy with a PSA= 2.5-10. Men were mandated to undergo a protocol-dependent biopsy at 2 & 4 yrs regardless of PSA. Race was self-reported. PC grade was classified as low (Gleason< 7) or high (Gleason> 7). Baseline clinical data were compared by race using rank-sum & chi-square. Uni-& multivariable logistic & multinomial regression were used to test if race predicts PC, grade (low vs high vs no PC) & biopsy compliance. Multivariable models were adjusted for age, PSA, BMI, DRE, prostate volume, region, treatment arm, PC family history & smoking.RESULTS: Black & white men had similar age, prostate volume, treatment arm, smoking status & PC …