Use of indirect evidence from HIV self-testing to inform the WHO hepatitis C self-testing recommendation

摘要: INTRODUCTION Evidence appraisal is a critical component of global health normative guidelines development by the World Health Organization (WHO). Since 2007, WHO’s handbook for guidelines development has outlined a structured and transparent process to ensure guidelines are informed by the latest evidence on intervention effectiveness, feasibility of implementation and considerations on other important elements such as values and preferences of users and providers, resource use, equity and human rights. 1 Typically, guidelines development involves a systematic review of evidence, appraisal of the certainty of evidence in accordance with the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) framework 2 and formulation of recommendations by an independent guidelines development group of experts. These guidelines groups typically comprise providers …