INFLUENCE OF THE METHOD OF PREPARATION ON PHYSICOCHEMICAL CHARACTERISTICS OF 1: 1 SIMVASTATIN-β-CYCLODEXTRIN INCLUSION COMPLEX.
作者： Emma Adriana Budura , Dumitru Lupuleasa , Corina Aramă , Mihai Niţulescu , Victoria Hîrjău
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摘要: The aim of the present study was to confirm the formation of 1: 1 molar ratio inclusion complexes between the practically insoluble drug, simvastatin (SV) and beta-cyclodextrin (β-CD) in aqueous solution and in solid states by different techniques. Complexation in solution was evaluated using Higuchi-Connors phase solubility studies. Phase solubility diagram was classified as A
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