Dairy based-LAB improved constipation via increasing fecal bulk and decreasing concentration of fecal threonine while preserving colonic goblet cell count

摘要: Constipation, which refers to difficulties in defecation and infrequent bowel movement in emptying the gastrointestinal system that ultimately produces hardened fecal matters, is a health concern in livestock and aging animals. The present study aimed to evaluate the potential effects of dairy-isolated LAB strains to alleviate constipation as an alternative therapeutic intervention for constipation treatment in the aging model. Rats were aged via daily subcutaneous injection of D-galactose (600 mg/body weight (kg)), prior to induction of constipation via oral administration of loperamide hydrochloride (5 mg/body weight (kg)). LAB strains (L. fermentum USM 4189 orL. plantarum USM 4187) were administered daily via oral gavage (10 log CFU/day) while the control group received sterile saline. Aged rats as shown with shorter telomere lengths exhibited increased fecal bulk and soften fecal upon administration of LAB …